development of 153sm/177lu-edtmp as a possible therapeutic complex
نویسندگان
چکیده
introduction:targeted radionuclide therapy (trt) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. trt is generally performed with a single radionuclide. in this study we investigated the feasibility of combined trt with a high-energy beta emitter (153sm) and a low energy beta emitter (177lu) in wistar rats. methods: the cocktail complex of 153sm/177lu-edtmp was prepared. to determine the effect of metal-to-ligand (me:edtmp) molar ratio on labeling yield, several complex were analyzed after changing me:edtmp molar ratio from 1:1 to 1:50. 153sm/177lu-edtmp was administered intravenously through the tail vein of wistar rats. biodistribution data were collected at 2 hours to 7 day post injection and scintigraphic images were taken at 24 hours and 1, 2 week after administration of radiopharmaceutical. results: the results revealed high skeletal uptake (3.5% and 3.4% id/g at 24 hours post injection for 153sm and 177lu, respectively) with rapid blood clearance and minimal uptake in any of the major organs. scintigraphic images verified high skeletal uptake. conclusion: our results indicate that the combination of 153sm and 177lu is feasible and safe. this study suggests that the combination of different radionuclides with different radiation energies and half-life, such as 153sm and 177lu, could be advantageous in patients with tumoral lesions of different sizes.
منابع مشابه
Development of 153Sm/177Lu-EDTMP as a possible therapeutic complex
Introduction:Targeted radionuclide therapy (TRT) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. TRT is generally performed with a single radionuclide. In this study we investigated the feasibility of combined TRT with a high-energy beta emitter (153Sm) and a low energy beta emitter (177Lu) in wistar...
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عنوان ژورنال:
iranian journal of nuclear medicineجلد ۲۵، شماره ۱، صفحات ۱۱-۱۶
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